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  <xs:element id="crl_ContractWithCustomerAssetPercentageOfAmountReclassifiedToReceivable" abstract="false" name="ContractWithCustomerAssetPercentageOfAmountReclassifiedToReceivable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_ContractWithCustomerPercentageOfLiabilitiesRecognizedAsRevenue" abstract="false" name="ContractWithCustomerPercentageOfLiabilitiesRecognizedAsRevenue" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_ContractWithCustomerUnpaidAdvancedClientBillings" abstract="false" name="ContractWithCustomerUnpaidAdvancedClientBillings" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_AccountsReceivableCreditLossExpenseReversalNetOfRecovery" abstract="false" name="AccountsReceivableCreditLossExpenseReversalNetOfRecovery" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_ResearchModelsAndServicesSegmentMember" abstract="true" name="ResearchModelsAndServicesSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_OtherMember" abstract="true" name="OtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_InventoryStepUpAmortization" abstract="false" name="InventoryStepUpAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_StrategicInvestmentsMember" abstract="true" name="StrategicInvestmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_EquityMethodInvestmentsCapitalContributions" abstract="false" name="EquityMethodInvestmentsCapitalContributions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_EquityMethodInvestmentsDecreaseDueToAcquisition" abstract="false" name="EquityMethodInvestmentsDecreaseDueToAcquisition" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_EquityMethodInvestmentForeignCurrencyTranslation" abstract="false" name="EquityMethodInvestmentForeignCurrencyTranslation" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_OtherLiabilitiesCurrentFairValueDisclosureAbstract" abstract="true" name="OtherLiabilitiesCurrentFairValueDisclosureAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_ContingentConsiderationMember" abstract="true" name="ContingentConsiderationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityChangeInPreviouslyRecordedAdjustment" abstract="false" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityChangeInPreviouslyRecordedAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_FairValueMeasurementWithUnobservableInputsReconciliationWeightedAverageProbabilityOfMaximumTarget" abstract="false" name="FairValueMeasurementWithUnobservableInputsReconciliationWeightedAverageProbabilityOfMaximumTarget" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_SeniorNotesDue2028Member" abstract="true" name="SeniorNotesDue2028Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_SeniorNotesDue2029Member" abstract="true" name="SeniorNotesDue2029Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_SeniorNotesDue2031Member" abstract="true" name="SeniorNotesDue2031Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_DiscoveryServicesMember" abstract="true" name="DiscoveryServicesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_BiologicSolutionsMember" abstract="true" name="BiologicSolutionsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_AcceleratedAmortizationOfIntangibleAssets" abstract="false" name="AcceleratedAmortizationOfIntangibleAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable" abstract="true" name="ScheduleOfFiniteLivedAndIndefiniteLivedIntangibleAssetsByMajorClassTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="crl_OtherLongTermDebtMember" abstract="true" name="OtherLongTermDebtMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_LongTermDebtGrossAndLeaseObligation" abstract="false" name="LongTermDebtGrossAndLeaseObligation" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_LongTermDebtAndLeaseObligationNetOfCurrentPortion" abstract="false" name="LongTermDebtAndLeaseObligationNetOfCurrentPortion" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_CreditFacilityMember" abstract="true" name="CreditFacilityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_SeniorNotesDue2029And2031Member" abstract="true" name="SeniorNotesDue2029And2031Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_DebtInstrumentCovenantEBITDALessCapitalExpendituresToConsolidatedCashInterestExpenseRatioMinimum" abstract="false" name="DebtInstrumentCovenantEBITDALessCapitalExpendituresToConsolidatedCashInterestExpenseRatioMinimum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="crl_DebtInstrumentCovenantConsolidatedIndebtednessToConsolidatedEBITDAMaximum" abstract="false" name="DebtInstrumentCovenantConsolidatedIndebtednessToConsolidatedEBITDAMaximum" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="crl_ScheduleOfStockRepurchasesTable" abstract="true" name="ScheduleOfStockRepurchasesTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="crl_PriorStockRepurchaseAuthorizationMember" abstract="true" name="PriorStockRepurchaseAuthorizationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_NewStockRepurchaseAuthorizationMember" abstract="true" name="NewStockRepurchaseAuthorizationMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_StockRepurchasesLineItems" abstract="true" name="StockRepurchasesLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_VitalRiverMember" abstract="true" name="VitalRiverMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_SupplierMember" abstract="true" name="SupplierMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_RedeemableNoncontrollingInterestDividendReceivableFairValue" abstract="false" name="RedeemableNoncontrollingInterestDividendReceivableFairValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_NoncontrollingInterestAdditionalOwnershipPercentageAcquiredByParent" abstract="false" name="NoncontrollingInterestAdditionalOwnershipPercentageAcquiredByParent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_RedeemableNoncontrollingInterestPurchasePricePayable" abstract="false" name="RedeemableNoncontrollingInterestPurchasePricePayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_EffectiveIncomeTaxRateReconciliationTaxCreditsAndDeductions" abstract="false" name="EffectiveIncomeTaxRateReconciliationTaxCreditsAndDeductions" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_DeferredTaxLiabilitiesTaxOnUnremittedEarningsPercent" abstract="false" name="DeferredTaxLiabilitiesTaxOnUnremittedEarningsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_EffectiveIncomeTaxRateReconciliationImpactOfAcquisitionsPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationImpactOfAcquisitionsPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_EffectiveIncomeTaxRateReconciliationForeignLocalTaxPercent" abstract="false" name="EffectiveIncomeTaxRateReconciliationForeignLocalTaxPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="crl_DeferredTaxAssetsOperatingLossAndCreditCarryforwards" abstract="false" name="DeferredTaxAssetsOperatingLossAndCreditCarryforwards" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_DeferredTaxAssetsOperatingLeaseLiability" abstract="false" name="DeferredTaxAssetsOperatingLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_DeferredTaxLiabilitiesDeferredExpenseDepreciation" abstract="false" name="DeferredTaxLiabilitiesDeferredExpenseDepreciation" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_DeferredTaxLiabilitiesTaxOnUnremittedEarnings" abstract="false" name="DeferredTaxLiabilitiesTaxOnUnremittedEarnings" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset" abstract="false" name="DeferredTaxLiabilitiesOperatingLeaseRightOfUseAsset" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_TaxCreditCarryforwardsByExpirationPeriodAxis" abstract="true" name="TaxCreditCarryforwardsByExpirationPeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="crl_TaxCreditCarryforwardsByExpirationPeriodDomain" abstract="true" name="TaxCreditCarryforwardsByExpirationPeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_TaxCreditCarryforwardsExpirationRange2Member" abstract="true" name="TaxCreditCarryforwardsExpirationRange2Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_DeferredTaxAssetValuationAllowanceRollForward" abstract="true" name="DeferredTaxAssetValuationAllowanceRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_DeferredTaxAssetValuationAllowanceAdditionsDeductionsForIncomeTaxExpenseBenefit" abstract="false" name="DeferredTaxAssetValuationAllowanceAdditionsDeductionsForIncomeTaxExpenseBenefit" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_DeferredTaxAssetValuationAllowanceReductionsForDisposalsRestructuring" abstract="false" name="DeferredTaxAssetValuationAllowanceReductionsForDisposalsRestructuring" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_DeferredTaxAssetValuationAllowanceAdditionsReductionsForCurrencyTranslationAndOther" abstract="false" name="DeferredTaxAssetValuationAllowanceAdditionsReductionsForCurrencyTranslationAndOther" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_OtherPlanAssetCategoriesMember" abstract="true" name="OtherPlanAssetCategoriesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_DeferredCompensationArrangementWithIndividualDeferralPeriod" abstract="false" name="DeferredCompensationArrangementWithIndividualDeferralPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="crl_DefinedContributionPlanEmployersMatchingContributionVestingPeriod" abstract="false" name="DefinedContributionPlanEmployersMatchingContributionVestingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="crl_DeferredCompensationArrangementWithIndividualPeriodOfHighestConsecutiveYearsOfCompensationUsedForDeterminationOfExecutiveSupplementalLifeInsuranceRetirementPlanBenefit" abstract="false" name="DeferredCompensationArrangementWithIndividualPeriodOfHighestConsecutiveYearsOfCompensationUsedForDeterminationOfExecutiveSupplementalLifeInsuranceRetirementPlanBenefit" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="crl_DefinedBenefitPlanActuarialGainLossChangeinMortalityAssumptions" abstract="false" name="DefinedBenefitPlanActuarialGainLossChangeinMortalityAssumptions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_DefinedBenefitPlanContributionsByEmployerToParticipantsOutsideOfPlanAssets" abstract="false" name="DefinedBenefitPlanContributionsByEmployerToParticipantsOutsideOfPlanAssets" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesPerEmployeeAvailableToPurchase" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesPerEmployeeAvailableToPurchase" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="crl_MaxPsuShares" abstract="false" name="MaxPsuShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="crl_ShareBasedCompensationArrangementsByShareBasedPaymentAwardFairValueAssumptionsChangeInWeightedAverageStockPrice" abstract="false" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardFairValueAssumptionsChangeInWeightedAverageStockPrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="crl_TradingDayAverageStockPriceOnGrantDate" abstract="false" name="TradingDayAverageStockPriceOnGrantDate" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="crl_SeveranceAndTransitionCostsMember" abstract="true" name="SeveranceAndTransitionCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="crl_AssetImpairmentsMember" abstract="true" name="AssetImpairmentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_OtherCostsMember" abstract="true" name="OtherCostsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="crl_CashFlowLesseeAbstract" abstract="true" name="CashFlowLesseeAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" abstract="true" name="RightOfUseAssetObtainedInExchangeForLeaseLiabilityAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_WeightedAverageRemainingLeaseTermAbstract" abstract="true" name="WeightedAverageRemainingLeaseTermAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_LeasesWeightedAverageDiscountRateAbstract" abstract="true" name="LeasesWeightedAverageDiscountRateAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="crl_LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" abstract="false" name="LesseeOperatingLeaseLeaseNotYetCommencedUndiscountedAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_InsurancePoliciesDeductible" abstract="false" name="InsurancePoliciesDeductible" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_PropertyInsuranceDeductible" abstract="false" name="PropertyInsuranceDeductible" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="crl_RepresentationAndWarrantyInsuranceDeductible" abstract="false" name="RepresentationAndWarrantyInsuranceDeductible" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
